Cholesterol-busting statins may help diabetics too: study
18 Jul 2014
Cholesterol-lowering statin-based drugs may have the extra benefit of helping prolong the lives of people with diabetic cardiovascular disease, new research has found.
Heart disease and stroke are the leading causes of death and disability among people with Type 2 diabetes, which mainly affects adults.
At least 65 per cent of people with diabetes die from some form of heart disease or stroke, according to the American Heart Association.
The new study by researchers at Wake Forest Baptist Medical Center suggests that the use of cholesterol-lowering statins may help prolong the lives of people with diabetic cardiovascular disease.
"Although our study was not a clinical trial, it did show that people with diabetes and heart disease can live quite a few years longer by taking statins," said Don Bowden, professor of biochemistry at Wake Forest Baptist and lead author of the study.
The research team studied data from 371 patients who had participated in the 'diabetes heart study'.
At the beginning of the study, the participants received a CT scan to determine their levels of coronary artery calcium (CAC). A CAC score greater than 1,000 indicates an increased risk of cardiovascular disease (CVD).
The team compared the baseline characteristics of 153 patients who died during an average 8.2 years of follow-up and 218 who survived.
The researchers assumed that risk for mortality would be consistently high among the study participants. However, 60 per cent were still living after more than eight years.
The use of cholesterol-lowering statins at the baseline exam was the only modifiable risk factor identified to be protective against mortality.
The participants taking statins at the beginning of the study had a 50 per cent increase of being alive as compared to those who didn't.
Bowden said this highlights the importance of widespread prescription of cholesterol-lowering medications among individuals with Type 2 diabetes who have existing high CVD risk, but added that in previous studies the rates of statins prescribed for diabetic patients have been low.
"These data suggest that cholesterol-lowering medications may be used less than recommended and need to be more aggressively targeted as a critical modifiable risk factor," he said.
The study is published in the journal Diabetes Care.
