Envelope for an artificial cell
25 January 2012
Chemists have taken an important step in making artificial life forms from scratch. Using a novel chemical reaction, they have created self-assembling cell membranes, the structural envelopes that contain and support the reactions required for life.
Neal Devaraj, assistant professor of chemistry at the University of California, San Diego, and Itay Budin, a graduate student at Harvard University, report their success in the Journal of the American Chemical Society.
''One of our long term, very ambitious goals is to try to make an artificial cell, a synthetic living unit from the bottom up – to make a living organism from non-living molecules that have never been through or touched a living organism,'' Devaraj said. ''Presumably this occurred at some point in the past. Otherwise life wouldn't exist.''
By assembling an essential component of earthly life with no biological precursors, they hope to illuminate life's origins.
''We don't understand this really fundamental step in our existence, which is how non-living matter went to living matter,'' Devaraj said. ''So this is a really ripe area to try to understand what knowledge we lack about how that transition might have occurred. That could teach us a lot – even the basic chemical, biological principles that are necessary for life.''
Molecules that make up cell membranes have heads that mix easily with water and tails that repel it. In water, they form a double layer with heads out and tails in, a barrier that sequesters the contents of the cell.