Brain imaging technique: New hope for understanding Parkinson's disease
10 March 2011
A non-invasive brain imaging technique gives new hope to patients with Parkinson's disease in finding new and better treatment plans and tracking the disease progression, a new University of Michigan study shows.
The technique uses an MRI to measure resting state brain activity oscillations, said Rachael Seidler, associate professor in the School of Kinesiology and the Department of Psychology, and study author.
Neural oscillations in a resting state are normal, Seidler said. However, in the part of the brain affected by Parkinson's, called the basal ganglia, those neural oscillations go haywire and spill into other parts of the brain, causing cognition, movement, memory and other problems. Think of a ripple in a pond spreading and disturbing the entire surface of the pond. Previously these neural oscillations were only available for study during brain surgery or in animal models.
One drug that reduces these oscillations and subsequent disturbances in Parkinson's is L-DOPA, Seidler said. Research subjects who hadn't taken their morning L-DOPA came in twice for testing and either received a placebo pill or L-DOPA. When scanned in the MRI, the images showed that the increased oscillations were reduced by the L-DOPA.
"The change in brain activity correlated with improvements in symptoms when patients were on versus off the medication," Seidler said. "Thus we propose that the brain imaging technique we used should be a good, noninvasive approach for monitoring disease progression and evaluating new treatments."
Surprisingly, the MRI imaging found that in some cases the L-DOPA even slowed the oscillations too much-think of this as the pond freezing. "In this instance you could use it (the imaging) to titrate the dose," Seidler said.