Three-in-one 'supermolecule' could detect cancer early, help destroy tumours and monitor treatment
08 Nov 2012
The same protein could potentially be targeted to detect pre-cancerous breast cells; deliver radiotherapy to destroy tumours; and monitor the effectiveness of treatment, according to a Cancer Research UK study presented at the NCRI Cancer Conference in Liverpool on Tuesday, 6 November.
Oxford University scientists at the Cancer Research UK / MRC Gray Institute for Radiation Oncology and Biology showed in the laboratory that a technique monitoring high levels of a protein called Gamma H2AX, found in many pre-cancerous cell types including breast, lung and skin cancer, could be used to detect cancer early.
The team took microscopic images of fluorescent 'flag' molecules attached to an antibody which 'homes in' on and attaches to Gamma H2AX, to identify areas of DNA damage (DNA double-strand breaks). The fluorescent 'snap shots' of Gamma H2AX revealed the location of pre-cancerous breast cancer cells at a very early stage.
Professor Katherine Vallis, who led the study at the Cancer Research UK / MRC Gray Institute for Radiation Oncology and Biology at Oxford University, says, ''This early research reveals that tracking this important molecule could allow us to detect DNA damage throughout the body. If larger studies confirm this, the protein could provide a new route to detect cancer at its very earliest stage – when it is easier to treat successfully.''
Previously the team modified an antibody to target Gamma H2AX and deliver radiotherapy to breast cancer cells which contained high levels of the protein. This form of radiotherapy works by boosting DNA damage until cells can no longer repair mistakes – and die.
The results confirmed that the radioactive antibody killed breast cancer cells and slowed tumour growth.
Prof Vallis added: ''We need to confirm these findings in larger studies before we know if this approach could benefit patients. But these initial results show that it may be possible to track down cells with high levels of DNA damage, and destroy them before they became cancerous.
