Daily dose of aspirin beneficial in gastrointestinal cancer: study

A study has revealed that a daily dose of aspirin could double the life expectancy of patients with cancers affecting the gastrointestinal tract.

It had been known that frequent use of aspirin could prevent bowel cancer, but the most recent study also suggested that men and women with a range of cancers who took the anti-inflammatory painkiller experienced a significant survival benefit as against those who did not.

According to the study of 14,000 cancer patients in the Netherlands, regular users of aspirin were twice as likely to still be alive following a four-year period as those who did not take the cheap drug.

The authors of the report revealed that the impact of aspirin on survival was seen after adjusting for factors such as gender, age, stage of cancer, treatments, and other medical conditions that could have influenced death rates.

According to trial coordinator, Dr Martine Frouws, from Leiden University in the Netherlands – who presented the findings at the 2015 European Cancer Congress in Vienna the findings could have a ''great impact'' on patients and national healthcare systems.

Over a typical follow-up period of four years, those using the drug after their diagnosis were twice as likely to still be alive as non-users.

The impact of aspirin on survival was seen after adjusting for factors such as gender, age, stage of cancer, treatments, and other medical conditions that could have influenced death rates.

Frouws, who presented the findings at the 2015 European Cancer Congress in Vienna, said, "Now we would like to analyse tumour material from these patients to try and discover which ones would benefit from aspirin treatment.

"Through studying the characteristics of tumours in patients where aspirin was beneficial, we should be able to identify patients who could profit from such treatment in the future.

"Given that aspirin is a cheap, off-patent drug with relatively few side-effects, this will have a great impact on healthcare systems as well as patients."

The most common tumour sites for patients in the study were the colon, rectum and oesophagus.

A new randomised controlled trial is currently investigating the effect of a daily low dose of 80 milligrams of aspirin on the survival of elderly patients with bowel cancer in the Netherlands.

In this trial, the effects of aspirin and a dummy "placebo" will be compared.

Researchers, who plan at a later date to expand the study to include gastrointestinal cancers, hope to provide "convincing proof" that more patients can benefit from aspirin treatment.

Professor Peter Naredi, scientific co-chair of the Congress, said, "We have good evidence that the frequent use of aspirin in the population can prevent some cases of colorectal (bowel) cancer. Now, Dr Frouws and colleagues show that in over 13,000 patients who were diagnosed with a gastrointestinal cancer, aspirin also improved survival compared with those who did not use it.

"With more and more data to support the beneficial role of aspirin, we must consider whether we should recommend it to a wider public."

Continual use of low-dose or regular-dose aspirin may cut a person's risk of developing pancreatic cancer in half, a Yale School of Public Health and Yale Cancer Center study has found. (See: Long-term use of aspirin may reduce risk for pancreatic cancer).