Wealthy Sheikhs from Qatar and Saudi Arabia who donated money to Hillary Clinton's charitable foundation also provided financial support to the dreaded jihadi group Isis, media reports quoted WikiLeaks founder Julian Assange as saying.
He believes this ''is the most significant email in the whole collection'' of an email exchange between Clinton and her campaign manager, leaked by his organisation last month.
In an extended interview at the Ecuadorian embassy in London with documentary maker John Pilger for RT, the WikiLeaks founder said the same Saudi and Qatari are supporting both the Clinton Foundation - founded by Clinton's husband Bill - and funding the activities of Isis.
Asked if Assange believed that "this notorious jihadist group, called Isil or Isis, is created largely with money from people who are giving money to the Clinton Foundation", Assange said, ''Yes."
In the email sent on 17 August 2014, Clinton asked Podesta, who at that time worked under president Barack Obama, to help put "pressure" on Qatar and Saudi Arabia regarding the countries' alleged support for the terrorist group Isis.
"We need to use our diplomatic and more traditional intelligence assets to bring pressure on the governments of Qatar and Saudi Arabia, which are providing clandestine financial and logistic support to Isil and other radical Sunni groups in the region," Clinton wrote.
Assange noted the US government had never acknowledged governments of Middle East nations had financially supported Isis, instead arguing such support was isolated to "some rogue princes using their cut of the oil money to do whatever they like, although the government disapproves", according to the WikiLeaks founder.
According to the Clinton Foundation, the Saudi Arabian government has donated between $10m (£8m) and $25million since the foundation was set up in 1997. Last month it was reported the government of Qatar offered to donate $1m to the foundation in celebration of Bill Clinton's birthday.
Representatives from the Clinton Foundation have repeatedly denied accusations Clinton has solicited funds and used donations to boost her campaign. There were no donations from Saudi Arabia while she was acting as secretary of state between 2009 and 2013.
Assange also used the interview to dismiss the prospect of a Donald Trump victory in next week's election, which the polls show will be close.
"My analysis is that Trump will not be permitted to win. Why do I say that? Because he has had every establishment against him. Trump does not have one establishment, maybe with the exception of the Evangelicals, if you can call them an establishment.
Assange unequivocally states that Trump will never be allowed to be President since pretty much everybody is ganged up against him.
"Banks, intelligence, arms companies, foreign money, etc are all united behind Hillary Clinton. And the media as well. Media owners, and the journalists themselves."
In October, Ecuador's government confirmed it had "temporarily restricted" Assange's internet access at its London embassy, to prevent him "meddling in the election process" in the US.