New pain relief targets discovered

24 Apr 2014

1

Scientists have identified new pain relief targets that could be used to provide relief from chemotherapy-induced pain. Biotechnology and Biological Sciences Research Council (BBSRC) is a UK Research Council-funded researchers at King's College London made the discovery when researching how pain occurs in nerves in the periphery of the body.

New pain relief targets discoveredDr Marzia Malcangio, Wolfson Centre for Age-Related Diseases,says,  "We have been investigating and identifying mechanisms underlying pain generation and our findings could help chemotherapy patients who suffer pain related side effects."

One potential side effect of some chemotherapy drugs (such as vincristine) is damage to nerves. This is particularly prominent in hands and feet as the drugs affect nerves in the periphery of the body. This causes pain which doctors treat with painkillers. However, some people find that the pain persists.

Dr Malcangio's team investigated why the chemotherapy drugs were causing pain in hope to solve the problem. The used mice in the study because mice given the chemotherapy drug also experienced pain in their nerve extremities (such as their hind-paws).

By studying the mice, they found that the pain was caused by the mouse's own immune system responding to damaged blood vessels.

Dr Marzia Malcangio explained: "The chemotherapy drug was found to cause damage to blood vessels around the nerves. When this happened, immune cells leave the blood flow and enter the nerve to help reduce the inflammation, but they also activate pain. Chemicals released naturally by the immune cells were activating the nerves and producing pain."

To try to prevent the pain, researchers looked at ways of stopping the immune cells entering the nerve. They identified receptors on the outside of the immune cells that could be targeted to stop their exit from blood, constituting new types of pain treatment

Dr Marzia Malcangio adds, "We have discovered that the pain responses are caused by local activation of pain nerves by immune cells and that this could be prevented. Our result can be exploited to produce drugs that, given in combination with treatment, may limit the pain experienced by patients during chemotherapy cycles."

Professor Jackie Hunter, BBSRC Chief Executive says, "This BBSRC CASE studentship has enabled a mutually beneficial research collaboration between academia and industry. Understanding the biological mechanisms of pain, using this mouse model, could lead to new types of pain management."

Business History Videos

History of hovercraft Part 3...

Today I shall talk a bit more about the military plans for ...

By Kiron Kasbekar | Presenter: Kiron Kasbekar

History of hovercraft Part 2...

In this episode of our history of hovercraft, we shall exam...

By Kiron Kasbekar | Presenter: Kiron Kasbekar

History of Hovercraft Part 1...

If you’ve been a James Bond movie fan, you may recall seein...

By Kiron Kasbekar | Presenter: Kiron Kasbekar

History of Trams in India | ...

The video I am presenting to you is based on a script writt...

By Aniket Gupta | Presenter: Sheetal Gaikwad

view more